Ngokunyuka kweemveliso zenikotini ezingenamsi, izingxobo zenikotini zingene ngokukhawuleza kwimarike yehlabathi ngenxa yeenzuzo zazo ezifana "nokungatshayi", "okufihliweyo", "incasa eninzi", kunye "nomxholo wenikotini olawulekayo". Abathengi ababhinqileyo baye baba liqela elibalulekileyo elinokubakho kolu didi ngenxa yeemfuno zabo ezikhethekileyo kumfanekiso wentlalo, iinkxalabo zempilo, kunye neemeko zokusetyenziswa. Eli nqaku liqala kwiimfuno zabasetyhini kwaye lidibanisa idatha yemarike kunye nophando lwezemfundo oluvela kumazwe afana ne-UK, i-US, iSweden, kunye ne-Australia ukucacisa ngokucwangcisiweyo ukufaneleka kunye neenzuzo zeengxowa ze-nicotine zabasetyhini.